Chemical Company in India
     
 
   
Propyl Paraben I.P
SYSTEM MANUAL
ISSUE NO : 01
Document No.
Revision No.
Effective date
Page
QAI/Q/03/16
03
5-Sep-08
1 of 1
PROPYL PARABEN I.P.
 
Chemical Name Propyl 4-Hydroxybenzoate
 Molecular Formula C10H12O3
 Molecular Weight 180.20


 Structural Formula
 CAS Number 94-13-3
 Packing 25 Kg, 20kg(4 x 5 kg)
 The Shelf-life 5 years
 Storage conditions and precautions Store in a well-closed containers.
 Use Antimicrobial Preservative
 
NO.
Test
Specifications
1.
 Description White crystalline powder; odourless.
2.
 Solubility Freely soluble in ethanol (95%), in acetone,  in ether and in Methanol; very slightly soluble in water.
3.
 Identification

A.       The light absorption in the range 230 to 360 nm of a 0.0005% w/v in ethanol (95%) exhibits a maximum at about 258 nm, absorbance at about 258 nm, 0.44 to 0.47

B.   To about 10 mg in a test tube add 1 ml of           sodium carbonate solution, heat to boiling for 30 seconds and cool (solution A) .To a further 10 mg in a test tube add 1 ml of sodium carbonate solution, the substance partly dissolves (solution B). Add at the same time to each of solutions A and B 5 ml of aminophenazone solution and 1 ml of potassium ferricyanide solution and mix. Solution B is yellow to orange brown. Solution A is orange to Red and the colour is clearly more intense than any similar colour that may be obtained with solution B..

4.
 Appearance of solution A 10% w/v solution in ethanol (95%) is clear or not more opalescence than Opalescence standard OS1 prepared by 5.0 ml of Opalescence standard & 95 ml of water .and not more intensely coloured than reference solution(BYS6) prepared by mixing 1.5 ml ferric chloride colorimetric solution, 0.8 ml cobaltous chloride colorimetric solution, 0.2 ml cupric sulphate colorimetric solution and 97.5 ml of 1% w/v HCl solution.
5.
 Acidity Dissolve 1.0 g in sufficient ethanol (95%) to produce 10 ml.  To 2 ml of the solution add 3 ml of ethanol (95%), 5 ml of carbon dioxide-free water and 0.1 ml of bromocresol green solution. Not more than 0.1 ml of 0.1M sodium hydroxide is required to change the colour of the solution.
6.
 Chloride Not more than 500 ppm.
7.
 Sulphate Heat 2 g with 100 ml of water, cool, add sufficient water to restore the original volume and filter.  To 10 ml of the filtrate add 0.15 ml of dilute hydrochloric acid and 0.1 ml of barium chloride solution; no turbidity is produced within 10 minutes.
8.
 Related  substances

Not more than 1.0 %.

9.
 Sulphated  ash

Not more than 0.1%

10. Loss on drying, % w/w Not more than 0.5 %
11.

Assay,%w/w (Ondried basis)

99.0 - 101.0%